History
The modern pistachio nut was first selected from wild Pistacia vera trees native to central Asia. The initial selection and improvement was first undertaken in the era of the Persian Empire which spanned from the Eastern Mediterranean to central Asia. Ever since, pistachios have been an important crop in cooler parts of the Iranian plateau.
Pistachio cultivation spread into the Mediterranean world where it has continuously prospered in Syria, Turkey, Greece and Sicily. Pistachios were already well known in Late Antiquity. Since 1970s, pistachios have become a commercial crop in many countries which fall around the 30th parallel north and south of the equator. These regions include: California, North Africa, New South Wales in Australia, South Africa, Argentina and Chile.
Since 1970s, pistachios have developed from a luxury nut appreciated only by the rich into a supermarket item enjoyed by all.
Botany
The pistachio of commerce is the only edible species among the 11 species in the genus Pistacia; all are characterized by their ability to exude turpentine or mastic. Several are referred to as pistachios, but the name is generally reserved for the edible nut of commerce. Its Latin name is Pistacia vera L. A member of the family Anacardiaceae, it is related to the cashew, mango, poison ivy and oak, pepper tree and sumac.
The Pistachio is a relatively small tree mostly grown in the arid parts of the world close to the 30th parallel latitude. It grows from sea level (e.g. Attica, Greece) up to an altitude of 1800 meter above sea level (e.g. Kerman, Iran). The combination of latitude and altitude should provide enough chilling hours in winter and long hot and sunny summer conditions to produce a viable crop.
Pistachios bear laterally on one-year-old wood. This causes an alternate bearing habit, very  prominent in pistachio production with extensive commercial consequences.
Pistachio tree is deciduous, i.e. it loses its leaves in the fall and remains dormant through the winter. The tree is dioecious (i.e. two houses), meaning the male flowers are borne on one tree and the female flowers on another. Therefore, both male and female trees are needed for nut production. The pollen is spread by wind.
The trees have extensive root systems allowing them to mine the soil deeply. Thus, pistachios are adapted to survive long periods of drought. They need a well-drained soil. In such soils, the tree can tolerate relatively high levels of salinity in soil and/or irrigation water.
Pistachios are characterized by a long juvenile period, typically bearing few nuts before six years of age. They achieve full bearing between 15 to 20 years of age.
http://fruitsandnuts.ucdavis.edu/dsadditions/Pistachio_Manual_2005/
Nut Morphology and Maturation
The individual pistachio nut grows in fruit clusters of multiple nuts, much like grapes. Botanically, they are drupes, the same classification for almonds, peaches, apricots, cherries and plums. All drupes consist of three parts; an exocarp, a fleshy mesocarp (together called hull) and an endocarp (shell) that encloses a seed (kernel). The difference between nuts and fruits lies in the edible portion. In pistachios and almonds the seed is consumed, rather than the mesocarp as in stone fruit.
Ripening of the fruit, late in summer, is signaled by the loosening and separation of hull from the shell and consequent splitting of the shell inside the loosened hull. In reality, not all nuts split open upon ripening. This depends on the cultivar (variety), weather conditions and irrigation schedule.
In all cultivars there exists a genetic aberration that causes shell splitting before hull separation (early splitting). This causes the splitting of the unripe hull which creates access for Aspergillus Flavus spores to the kernel. Such nuts, if not harvested quickly, may provide a good medium for the growth of Aspergillus and the creation of aflatoxin which is a secondary metabolite in the growth of the fungus. The percentage of early splits produced by the tree at the time of the harvest will differ from one variety to the other; it also varies from year to year depending on the weather and irrigation schedule. Early and quick harvest is the best practice in avoiding high levels of contamination by aflatoxin in the harvested crop.
http://fruitsandnuts.ucdavis.edu/dsadditions/Pistachio_Manual_2005/
Uses and Nutrition
Naturally split in-shell pistachios are generally sold as salted roasted product. It is the consumer that shells and eats the kernel. Alternatively, a smaller portion of the product is sold as kernels or green peeled pistachio kernels (GPPKs) to the sausage, confectionary and ice cream industry. In the industrial use, green peeled pistachio kernels are mostly added as an ingredient to give the product an aura of luxury.
Pistachios are a rich source of vitamins and minerals, fiber, antioxidants and œunsaturated fat for a healthy diet. A serving size of pistachios provides more nutrients than most other nuts and snacks:
28 grams of pistachios contains more dietary fiber than half a cup of broccoli or spinach.
28 grams of pistachios contains four times more vitamin B6 than peanut butter.
28 grams of pistachios contains as much thiamin as half a cup of cooked rice.
28 grams of pistachios has the same amount of potassium as a large banana.
28 grams of pistachios has 15 grams of fat, of which only 1.5 grams is saturated. Most of the fat in pistachios is unsaturated, similar to olive oil.

Nutrition Table:

Serving Size: 100 gr Energy: 594 kcal
Carbohydrate 19.0 g
Dietary Fiber 1.9 g
Protein 19.3 g
Fat, Total 56 g
Saturated 6 g
Polyunsaturated 20 g
Monounsaturated 28 g
Cholesterol 0 mg
Sodium 7 mg
Potassium 972 mg
Calcium 131 mg
Iron 7.3 mg
Phosphorus 500 mg
Magnesium 158 mg
Zinc 2.3 mg
Manganese 1.2 mg
Vitamin A 22 µg
Thiamin (Vitamin B1) 0.67 mg
Vitamin B6 1.7 mg
Folate (Vitamin B9) 67 µg
Vitamin E 4.6 mg

Source: Shacker Ardakani, A, "Pistachio Kernel and Its Role in Nutrition and Health" (Ministry of Agriculture, Agricultural Research and Education Organization, Iran Pistachio Research Institute, 2006)
Health Benefits of Pistachios
There have been numerous studies highlighting the health benefits of pistachios:
Heart Health
FDA published a statement in 2003 approving that scientific evidence suggests that eating 1.5 ounces per day of pistachios, as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease. Pistachios may help curb less-than-ideal levels of LDL "bad" cholesterol, according to another study published in 2008. In research at Pennsylvania State University, pistachios in particular significantly reduced levels of low-density lipoprotein (LDL cholesterol) while increasing antioxidant levels in the serum of volunteers.
Reducing Risk of Lung Cancer
According to data presented at the American Association for Cancer Research Frontiers in Cancer Prevention Research Conference, a diet that incorporates a daily dose of pistachios may help reduce the risk of lung cancer. According to the research, pistachios are a good source of gamma-Tocopherol, which is a form of vitamin E, and it is known that vitamin E provides a degree of protection against certain forms of cancer. Therefore it is thought that eating pistachios increases the intake of gamma-Tocopherol, so pistachios may help to decrease lung cancer risk.
Anti-Inflammatory Benefits
Research published in Molecular Nutrition & Food Research shows that pistachio oil decreases levels of an inflammatory marker known as "Ifit-2". Inflammation is a biological response to harmful stimuli, pathogens, damaged cells or irritants, and it underlies functional changes associated with many chronic diseases, such as obesity and cancer. The finding that pistachios decrease inflammation, a newly discovered risk factor, for cardiovascular disease as well as other diseases is further support for the key nutrition message about including pistachios in a healthy diet for chronic disease risk reduction.
Eating Behavior
In December 2008, Dr. James Painter, a behavioral eating expert professor and chair of School of Family and Consumer Sciences at Eastern Illinois University, described the Pistachio Principle. The Pistachio Principle describes methods of "fooling" one's body into eating less. One example used is that the act of de-shelling and eating pistachios one by one slows one's consumption allowing one to feel full faster after having eaten less.